Case report describes clear cell carcinoma arising from hepatic endometriosis, suggesting potential malignancy risks.
Endometriosis is a chronic estrogen-dependent disorder that is generally localized in the pelvis affecting up to 10% of women in the reproductive age. Extra-pelvic locations are estimated to 9% of endometriosis women. However, the spread of the disease to parenchymal organs such as the liver is rare. Moreover, malignant transformation of hepatic endometriosis is exceptional. Here, we present a case of hepatic clear cell carcinoma developed on endometriosis lesion in a patient with prior surgery for deep endometriosis with colorectal involvement.
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Chilà et al. (2026) studied this question.
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