March 18, 2024Molecular & Cellular OncologyOpen Access

Molecular analysis to identify novel potential biomarkers as drug targets in colorectal cancer therapy: an integrated bioinformatics analysis

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MGMansour K. GatashehKing Saud University SNSathan Raj NatarajanSaveetha University RKRajapandiyan KrishnamoorthyKing Saud University

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Integrated bioinformatics analysis reveals six oncogenic hub genes in colorectal cancer, highlighting novel diagnostic markers and therapeutic targets.

Key Points

Integrated bioinformatics analysis identified ABCE1, AURKA, HSPD1, PHKA1, CDK4, and YWHAE as critical oncogenic hub genes in colorectal cancer.
Screening isolated 114 differentially expressed genes from database records, and RT-PCR testing confirmed the upregulation of hub genes in HT-29 cells.
Bioinformatic profiling across survival curves and clinical stages highlights these hub genes as promising diagnostic markers in colorectal cancer.

Cite This Study

Gatasheh et al. (2024) studied this question.

synapsesocial.com/papers/68e73771b6db6435876b140f https://doi.org/10.1080/23723556.2024.2326699

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Integrated bioinformatics analysis reveals six oncogenic hub genes in colorectal cancer, highlighting novel diagnostic markers and therapeutic targets.

Molecular analysis to identify novel potential biomarkers as drug targets in colorectal cancer therapy: an integrated bioinformatics analysis

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Cite This Study

Molecular analysis to identify novel potential biomarkers as drug targets in colorectal cancer therapy: an integrated bioinformatics analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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