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November 18, 2025OncoOpen Access

Integrated Multi-Omics Analysis Identifies Novel Prognostic and Diagnostic Hub Genes in Colorectal Cancer

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Authors

DLDevi LalHPHimani Pandey

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Overview

Integrated analysis reveals genetic alterations linked to poor survival in colorectal cancer, suggesting new diagnostic strategies.

Key Points

  • The study aims to identify hub genes in colorectal cancer for improving diagnosis and prognosis.
  • Analyzed gene expression datasets from the GEO database.
  • Identified differentially expressed genes and hub genes using a multi-omics integration approach.
  • Assessed prognostic significance through overall survival analysis and diagnostic utility via ROC curve and AUC.
  • Identified 989 candidate hub genes related to colorectal cancer.
  • 128 genes showed significant prognostic potential linked to overall survival.
  • 23 hub genes demonstrated high diagnostic accuracy in distinguishing CRC from normal tissues.

Cite This Study

Lal et al. (2025) studied this question.

synapsesocial.com/papers/692509ddc0ce034ddc352185https://doi.org/10.3390/onco5040050
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Also Consider

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  1. 1Mitotic Hub Gene Network in Colorectal Cancer: Integrated Transcriptomic, Protein-Level, and Clinical-Genomic Characterization of a Ten-Gene Signature2026
  2. 2Molecular analysis to identify novel potential biomarkers as drug targets in colorectal cancer therapy: an integrated bioinformatics analysis2024 · 17 citations
  3. 3Identification of Hub genes with prognostic values in colorectal cancer by integrated bioinformatics analysis2024 · 11 citations
  4. 4Identification of prognostic gene markers for the early diagnosis of colorectal cancer2024
  5. 5A comprehensive multi-omics study reveals potential prognostic and diagnostic biomarkers for colorectal cancer2024 · 1 citations