March 15, 2024MedicineOpen Access

Identification and prognostic analysis of candidate biomarkers for lung metastasis in colorectal cancer

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YLYuxing LiuFirst People's Hospital of Chongqing CLChenming LiuTongji University DHDong HuangJiangsu University

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Bioinformatics analysis identifies candidate prognostic biomarkers in colorectal cancer lung metastasis, highlighting the diagnostic potential of APOE and SPP1.

Key Points

Candidate biomarkers APOE and SPP1 demonstrate significant prognostic value alongside forty-nine differentially expressed genes in colorectal cancer patients with lung metastasis.
Screening of 459 colorectal primary and lung metastatic profiles across three datasets identified key hub genes and established an interacting protein network.
Enrichment analysis indicates that immune responses and chemokine receptors drive colorectal cancer lung metastasis, but prospective clinical validation remains necessary.

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Liu et al. (2024) studied this question.

synapsesocial.com/papers/68e73cbeb6db6435876b6444 https://doi.org/10.1097/md.0000000000037484

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Bioinformatics analysis identifies candidate prognostic biomarkers in colorectal cancer lung metastasis, highlighting the diagnostic potential of APOE and SPP1.

Identification and prognostic analysis of candidate biomarkers for lung metastasis in colorectal cancer

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Cite This Study

Identification and prognostic analysis of candidate biomarkers for lung metastasis in colorectal cancer

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Key Points

Cite This Study

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