The role of corticosteroids in patients hospitalized for COVID-19 at Mexico general Hospital

Objective: To compare the evolution of hospitalized patients infected with SARS-CoV-2 who received corticosteroid-based treatment versus patients who received standard therapy.Method: Retrospective, observational, and analytical study.Clinical records were collected from the different intensive care units, and data were obtained from confirmed Patients with COVID-19 over 18 years of age who were hospitalized.The population was divided into two groups: patients who received corticosteroid treatment, and those who received standard therapy.Results: A total of 1603 patients were admitted to hospital, and of these 984 (62.9%) were discharged due to death.The main result was the identification by odds ratio (OR: 4.68; 95% confidence interval [95%CI]: 3.75-5.83;p = 0.001) as risk for death to the use of systemic steroids, as well as the use of invasive mechanical ventilation (OR: 2.26; 95%CI: 1.80-2.82;p < 0.001).The male gender was the most affected with 1051 (65.6%) patients.Mean age was 56 years (± 14).Conclusions: Corticosteroid use was associated with poor prognosis in patients hospitalized for COVID-19 compared to those receiving standard therapy.