Among the various non-invasive early cancer detection tools, micronucleus (MN) assay can be used as a diagnostic and prognostic marker to genotoxic and carcinogenic agents. The objective of this study was to compare and correlate MN frequency between pre-operative and post-operative (lesional & non-lesional) area in oral cancer patient. The study analyzed 36 patients with oral squamous cell carcinoma (OSCC) which were clinically diagnosed and histopathologically graded. The smear was taken from the mucosa surrounding lesion as well as from the opposite side; before and after surgical intervention. Collected smears were stained with acridine orange (AO) and examined for presence of MN in the exfoliated cells. Mean MN frequency was signicantly higher in peri-lesional area as compared to non-lesional area. It was concluded that, micronuclei (MNi) frequency can be considered as a good prognostic indicator following treatment outcomes in oral cancer.
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Maity et al. (2024) studied this question.
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