IDH targeted fluorescence guided surgery in low grade gliomas

Gross total resection of low grade gliomas is associated with prolonged time to malignant transformation and ultimately overall survival. Unfortunately, rates of gross total resection are reported to be as low as 20-40%. Current strategies in fluorescence guidance are lacking for low grade gliomas and represent an unmet need. We have developed a novel fluorescence exploiting the highly conserved IDH mutant protein that is present in >80% of these tumors. To date there are well described small molecule IDH mutant inhibitors in clinical trial. We describe the development of small molecule fluorescent inhibitors of the IDH mutant protein and their potential applications in surgery for LGG.