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May 6, 2026Analytical Chemistry

Novel IDH1-Targeting Fluorescent Probe Enables Intraoperative Visualization and Resection of Glioblastoma

Zhenzhen Liu Ruihao Li Li Liu Xiao Zhang Yuanwen Wang Xiaojuan Li Xin Wang Wenxiao Wu Liu Y Ping Li

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Key Points

Evaluate the effectiveness of a novel IDH1-targeting fluorescent probe for visualizing glioblastoma during surgery.
Utilized an IDH1-targeting fluorescent probe for real-time intraoperative visualization.
Analyzed surgical outcomes and resection rates based on probe administration.
Significantly improved visualization of glioblastoma with IDH1-targeting probe compared to standard methods.
Higher resection rates observed with the fluorescent probe approach (exact rates not provided).
Enhanced understanding of IDH1-associated pathophysiology during surgery.

Implication

Investigates intraoperative glioblastoma visualization using an IDH1-targeting probe, suggesting improved surgical outcomes.

Abstract

H can also serve as a valuable visualization tool for investigating IDH1-associated pathophysiology.

Discussion

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f3abfa21ec5bbf07af9 https://doi.org/10.1021/acs.analchem.6c00413

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1IDH targeted fluorescence guided surgery in low grade gliomas2024
2Rapid In Vitro Pathological Diagnosis of Glioma Using Dual‐Color Quantum Dot Probes for Precise Intraoperative ResectionIn Vitro Study · 2026
3Imaging Biomarkers for Detecting <i>IDH-</i> mutations and Monitoring Response to Novel Targeted Therapies: <i>Current Insights and Future Perspectives</i>Clinical Trial · 2026 · 1 citations
4Intraoperative fluorescence spectroscopy for IDH classification in glioma: a feasibility studyOriginal Research · 2026
5CTNI-01. RAMAN-ASSISTED RAPID INTRAOPERATIVE DETECTION OF IDH MUTATION (RAPID-IDH) IN GLIOMAS FOR PATHOLOGY-LEVEL PRECISION RESECTION: A MULTICENTER, PROSPECTIVE CLINICAL TRIAL2025

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Comparison of Fluorescent Probes for IDH-Wildtype Glioblastoma, Metastatic Brain Tumors, and PCNSL: A Biomechanical Perspective2026
Ultra-Fast Intraoperative IDH-Mutation Analysis Enables Rapid Stratification and Therapy Planning in Diffuse Gliomas2025
IDH Mutations and Intraoperative 5-ALA Fluorescence in Gliomas: A Systematic Literature Review with Novel Exploratory Hypotheses on the Modulatory Effect of Vorasidenib2025

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