Metasurface-enhanced nanospectroscopy and molecular diagnostics towards quantum biomedical engineering

In this talk, I will introduce metasurface-enhanced multiplexed nanospectroscopy and molecular diagnostics. First, we report metasurfaces-driven hyperspectral imaging via multiplexed plasmon resonance energy transfer to probe biological light-matter interactions, which can detect quantum biological electron transfer. We conduct real-time and label-free monitoring of reactive oxygen species (ROS) from different types of cells. We used three different cells, normal cells, tumor cells, and drug-treated tumor cells, and quantitatively analyzed ROS production in real-time. Second, we scalably fabricate a low-power-consuming metaphotonic PCR device composed of a metamaterial perfect absorber that can rapidly go through thermocycling steps using a single infrared LED. We demonstrate an ultrafast photonic reverse transcription PCR (RT-PCR) with 30 thermocycles achieving 21.9 °Cs-1 heating rate and 7.8 °Cs-1 cooling rate. Furthermore, we would like to utilize the metaphotonic PCR chip for quantitative quantum enzymology.