Preclinical study shows that topical carbon monoxide gas-entrapping materials accelerate wound repair in diabetic mice, highlighting therapeutic potential for non-healing ulcers.
Diabetic wound healing is uniquely challenging to manage due to chronic inflammation and heightened microbial growth from elevated interstitial glucose. Carbon monoxide (CO), widely acknowledged as a toxic gas, is also known to provide unique therapeutic immune-modulating effects. To facilitate delivery of CO, we have designed hyaluronic-acid-based CO gas-entrapping materials (CO-GEMs) for topical and prolonged gas delivery to the wound bed. We demonstrate that CO-GEMs promote the healing response in murine diabetic wound models (full-thickness wounds and pressure ulcers) compared to N2-GEMs and untreated controls.
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Witt et al. (2024) studied this question.
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