Background New guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional considerations in trial methodologies. Main body We present non-inferiority trials to overcome ethical issues with placebo use, and additionally discuss issues with trial recruitment. Conclusions We highlight some possible issues and solutions to be considered with the recently published cluster headache trial guidelines.
No takes yet. Share an insight, caveat, or question.
Medrea et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: