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March 7, 2024HaematologicaOpen Access

Prognostic impact of SF3B1 mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases

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Authors

FFFaiqa FarrukhJefferson HospitalMAMaymona AbdelmagidMayo ClinicAMAbhishek A. MangaonkarMayo Clinic

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Implication

Observational study reveals multilineage dysplasia predicts survival in myelodysplastic syndromes with ring sideroblasts, indicating morphological classification surpasses mutational grouping.

Key Points

  • Multilineage dysplasia significantly reduces overall survival in myelodysplastic syndromes with ring sideroblasts, whereas SF3B1 mutation status shows no prognostic impact.
  • A hazard ratio of 1.8 confirmed multilineage dysplasia independently worsened survival, whereas SF3B1 mutation status showed no significant difference.
  • Analysis of registry records from 170 patients suggests multilineage dysplasia is prognostically superior to SF3B1 mutation for disease classification and leukemia-free survival risk.

Cite This Study

Farrukh et al. (2024) studied this question.

synapsesocial.com/papers/68e75556b6db6435876ccf49https://doi.org/10.3324/haematol.2023.284719
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts2008 · 338 citations
  2. 2The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia2016 · 10,415 citations
  3. 3Proposals for the classification of the myelodysplastic syndromes1982 · 1,278 citations
  4. 4A natural history of lower-risk myelodysplastic syndromes with ring sideroblasts: an analysis of the MDS-CAN registry2022 · 6 citations