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December 8, 2025BloodOpen Access

Not all that glitters is gold: A simple clinical score to unmask adverse SF3B1WT MDS-RS with low blast count

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Authors

MDMaría Diez‐CampeloFAFrancesco Annunziato

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Overview

Analysis shows a predictive score for SF3B1WT in myelodysplastic syndromes, indicating need for closer monitoring.

Key Points

  • The aim is to identify markers predictive of SF3B1WT in low blast count MDS-RS cases.
  • Analyzed MDS-RS data excluding specific subgroups.
  • Defined RS positivity per WHO criteria.
  • Compared clinical features using logistic regression analysis.
  • Developed a predictive score based on clinical parameters.
  • Identified distinct features in SF3B1WT cases, including worse overall survival.
  • SF3B1WT cases had significantly lower platelet and neutrophil counts.
  • Developed score showed high sensitivity and specificity for predicting SF3B1WT.

Cite This Study

Diez‐Campelo et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da35https://doi.org/10.1182/blood-2025-5623
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