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December 8, 2025BloodOpen Access

Predictive value of red cell distribution width for SF3B1 mutation status in myelodysplastic neoplasms

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Authors

CHCyrus C. Hsia

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Overview

Retrospective analysis reveals red cell distribution width may hint at SF3B1 mutations in MDS, indicating the need for further exploration.

Key Points

  • Evaluate the predictive value of red cell distribution width for SF3B1 mutation status in myelodysplastic neoplasms.
  • Retrospective review of adults diagnosed with MDS at a tertiary care centre.
  • Assessment of patients with SF3B1 mutation testing via next-generation sequencing.
  • Comparison of RDW and platelet counts between SF3B1-mutated and wild-type cases.
  • Evaluation of RDW using receiver operating characteristic curves
  • 21 out of 165 patients had SF3B1 mutations (12.7%).
  • RDW was higher in SF3B1-mutated cases but had modest discrimination (AUC 0.632).
  • A threshold of 18.6% RDW yielded 65% sensitivity and 67% specificity.
  • Platelet counts were significantly higher in mutated cases, with an AUC of 0.844.

Cite This Study

Cyrus C. Hsia (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e07bhttps://doi.org/10.1182/blood-2025-7401
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Not all that glitters is gold: A simple clinical score to unmask adverse SF3B1WT MDS-RS with low blast count2025
  2. 2Myelodysplastic Neoplasms (MDS) with Ring Sideroblasts or SF3B1 Mutations: The Improved Clinical Utility of World Health Organization and International Consensus Classification 2022 Definitions, a Single-Centre Retrospective Chart Review2024 · 7 citations
  3. 3Identification of red cell distribution width as a key predictor of leukemic transformation in polycythemia vera and essential thrombocythemia: A machine learning approach involving 10,560 cases2025
  4. 4Red Cell Distribution Width as an Independent Prognostic Biomarker in MASLD2026
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