Association between CACNA1C gene polymorphism rs1006737 and risk of Bipolar disorder: a meta-analysis

The meta-analysis was to investigate the relationship between the calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) gene polymorphism rs1006737 and risk of BP. The search was made in PubMed, Embase, Cochrane Library, and Web of Science databases until December 2023. This meta-analysis was conducted using Stata 14.0 software. The CACNA1C gene polymorphism rs1006737 showed a significantly higher risk with BP for the allele model (A vs. G: OR = 1.311, 95%CI = 1.148–1.497, p <0.000), codominant 1 model (GA vs. GG: OR = 1.356, 95%CI = 1.136–1.618, p = 0.001), codominant 2 model (AA vs. GG: OR = 1.474, 95%CI = 1.202–1.806, p <0.000), dominant model (GA + AA vs. GG: OR = 1.403, 95%CI = 1.181–1.667, p <0.000), recessive model (AA vs. GG + GA: OR = 1.324, 95%CI = 1.092–1.605, p = 0.004), and over dominant model (GG + AA vs. GA: OR = 0.807, 95%Cl = 0.680–0.958, p = 0.016). However, results from subgroup analysis showed a significant relationship between the CACNA1C gene polymorphism rs1006737 and BP risk in allele (A vs. G: OR = 1.326, 95%CI = 1.163–1.511, p <0.000), codominant 1 model (GA vs. GG: OR = 1.343, 95%CI = 1.109–1.627, p = 0.003), codominant 2 model (AA vs. GG: OR = 1.548, 95%CI = 1.256–1.907, p <0.000), dominant model (GA + AA vs. GG: OR = 1.411, 95%CI = 1.180–1.689, p <0.000), recessive model (AA vs. GG + GA: OR = 1.378, 95%CI = 1.131–1.679, p = 0.001) in Caucasian, but not in Asian.This meta-analysis suggests that CACNA1C gene polymorphism rs1006737 is associated with a higher risk of BP in the overall population and Caucasian population, but not in Asian population.