Key result
CACNA1C SNP rs1006737 is linked to ~38% higher schizophrenia risk and elevated major depression risk.
Why the study?
Is the CACNA1C gene associated with susceptibility to schizophrenia and major depressive disorder in the Han Chinese population?
Case-Control (n=3,515)
No
Is the CACNA1C gene associated with susceptibility to schizophrenia and major depressive disorder in the Han Chinese population?
Odds Ratio: 1.384 (95% CI 1.134–1.69)
p-value: p=0.0014
The CACNA1C gene variant rs1006737 is a shared risk factor for both schizophrenia and major depressive disorder in the Han Chinese population.
Does not alter clinical management; leaves open replication, functional validation, and broader applicability in psychiatric genetics.
BACKGROUND: Common psychiatric disorders are highly heritable, indicating that genetic factors play an important role in their aetiology. The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder. AIMS: To investigate whether CACNA1C is a susceptibility gene for schizophrenia and major depressive disorder in the Han Chinese population. METHOD: We carried out a case-control study of 1235 patients with schizophrenia, 1045 with major depressive disorder and 1235 healthy controls. A tag single nucleotide polymorphism (SNP) rs1006737 along with another 10 tag SNPs in the CACNA1C gene were genotyped in all samples. RESULTS: We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752). CONCLUSIONS: Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.
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He et al. (2013) conducted a case-control in Schizophrenia and Major Depressive Disorder (n=3,515). CACNA1C gene SNP rs1006737 vs. Healthy controls was evaluated on Association of rs1006737 with schizophrenia (OR 1.384, 95% CI 1.134-1.690, p=0.0014). The CACNA1C gene SNP rs1006737 was significantly associated with an increased risk of both schizophrenia (OR 1.384) and major depressive disorder (OR 1.425) in the Han Chinese population.
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