A Clinical Study to Evaluate the Lipid Profile in the Age Group of 1 to 12 Years with Primary Nephrotic Syndrome

Introduction: Nephrotic syndrome is a clinical state characterized by massive proteinuria, hypoalbuminemia and edema. This study is made to collate the effectiveness of lipid profile by follow up of patients of nephrotic syndrome. Objectives: To evaluate the serum level of total cholesterol, triglycerides, HDL, LDL, VLDL levels in children (aged 1 -12years) with primary nephrotic syndrome for a period of 12 weeks duration. Methods: This prospective study was performed on 50 children with primary nephrotic syndrome who are attending to paediatric OPD of Katuri medical college & Hospital, Chinakondrupadu, Guntur. They were clinically examined and lipid profile was done at the onset of disease and on follow up at the 6 th and 12 th weeks. Results: The present study consists of 50 cases of children with idiopathic nephrotic syndrome aged between 1 and 12 years. Among the patients involved in the study, all patients were followed up at 6 & 12 week visits. Among 50 cases studied, the maximum number of cases were in the age group of 36 to 60 months (62%), male to female ratio was 3: 1, facial puffiness and edema was present in 90% of cases and decreased urine output in 10% cases.Hypoprotenemia and hypoalbuminaemia was present in all 100% cases.Hypercholesterolemia, hypertriglyderidemia, elevated LDL, VLDL was seen in all cases (100%).The p -value was <0.05.The mean cholesterol, triglyceride level, LDL, VLDL levels were significantly higher in relapse cases compared to the 1 st episode of nephrotic syndrome.Conclusion: The present study shows that in nephrotic syndrome, there is hyper -lipidemia in all cases but it was significantly higher in cases of relapse compared to the 1 st episode of nephrotic syndrome.