Key result
Active nephrotic syndrome linked to ~2-fold higher total cholesterol, with dyslipidemia persisting in relapsing cases.
Why the study?
Hyperlipidemia is typically detected in active nephrotic syndrome and normalizes with resolution of proteinuria, but lipid profile changes during active disease and remission in children with NS need assessment.
Observational (n=60)
No
Absolute Event Rate: 384.6% vs 195.2%
p-value: p=<0.001
Children with frequently relapsing and steroid-dependent nephrotic syndrome experience persistently elevated total cholesterol and triglycerides even during clinical remission, highlighting the need for prolonged lipid monitoring.
Persistent hyperlipidemia post-remission in frequent relapsers may warrant extended monitoring; leaves open whether intervention alters outcomes in pediatric nephrotic syndrome.
Background and Aim: Hyperlipidemia is typically detected in active nephrotic syndrome(NS) and normalizes with the resolution of the proteinuria. This study assessed the lipidprofile of children with NS during active disease and remission.Methods: This prospective observational study was conducted at ICMH, Bangladesh, fromJuly 2021 to June 2022. Sixty children with NS (1-18 years), including both first attack andrelapse cases, were enrolled. A detailed history and thorough clinical examination were carriedout. Serum fasting lipid profiles were measured during active disease and again 4 weeksafter achieving remission. After collecting all the required data, analysis was conducted usingSPSS software, version 24.0.Results: The majority of children (70%) were relapse cases. The mean age of the studyparticipants was 5.15±2.97 years, with a predominance of males (61.7%). Mean serumcholesterol, low-density lipoprotein (LDL), and triglycerides (TG) levels were elevated inall groups, while high-density lipoprotein (HDL) levels were normal in all groups duringactive disease. During remission, serum cholesterol, TG, and LDL levels were significantlyreduced in both first attack and relapse cases. LDL levels returned to normal in all groups,but total cholesterol (TC) and TG remained high in the frequently relapsing NS (FRNS) andsteroid-dependent NS (SDNS) groups. Serum albumin levels were low in all groups, withsignificantly lower levels observed in the FRNS group.Conclusion: During active disease, serum cholesterol, TG, and LDL levels were elevated inboth first attack and relapse cases. Serum TC and TG remained persistently high in FRNSand SDNS.
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Zaman et al. (2025) conducted an observational in Nephrotic syndrome (n=60). Active nephrotic syndrome vs. Remission phase was evaluated on Mean total cholesterol levels (mg/dl) in first attack cases (p=<0.001). During active nephrotic syndrome, serum cholesterol, triglycerides, and LDL levels were significantly elevated, with total cholesterol and triglycerides remaining persistently high in frequently relapsing and steroid-dependent cases even after remission.
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