Evaluating the Efficacy and Safety of Intra - Articular Corticosteroid versus Hyaluronic Acid Injections in the Treatment of Knee Osteoarthritis: A Comparative Analysis of Randomized Controlled Trials

Overview: Articular cartilage deterioration is a prevalent, chronic joint condition known as osteoarthritis (OA) of the knee. It has been shown that intra -articular HA injections are helpful in the treatment of osteoarthritis (OA), since they improve the viscosity of synovial fluid and joint lubrication, restore hyaluronan synthesis, prevent proteoglycan breakdown, and have analgesic and antiinflammatory properties. For the past ten years, CS have been used to treat OA, and they seem to be reasonably safe. Because CS affect both the mechanisms that contribute to the functioning of inflammatory cytokines and the cytokines themselves, they have antiinflammatory actions. Materials and procedures: In order to find randomized controlled trials (RCTs) evaluating the safety or effectiveness of intraarticular corticosteroid injections against intraarticular hyaluronic acid injections for the treatment of knee osteoarthritis, two reviewers conducted an electronic literature search. Findings: At the conclusion of the first month (p = 0.018), therewas a significant difference in pain between the two groups; however, at the end of the second and third months (P = 00.167and P = 0.720), there was no significant difference.The physical function issue was considerably better in the groups receiving corticosteroids (P = 0.026) and Hylan (P = 0.043).Discussion: Over time, the various treatments' capacity to cure patients differed.The two medications (HA and CS) seemed to be equally beneficial for pain in the short term (≤1 month) according to the VAS of knee OA.But after at least three months, it was shown that HA had a higher relative impact than CS.