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March 4, 2024Blood Cancer Discovery

Abstract P23: RHOA inactivation subverts IFN-γ response and promotes antigen escape in CAR-T resistant diffuse large B-cell lymphoma

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Authors

ANAustin D. NewsamUniversity of MiamiCCCaroline A. CoughlinUniversity of MiamiYGYitzhar GoretskyUniversity of California, Santa Cruz

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Cite This Study

Newsam et al. (2024) studied this question.

synapsesocial.com/papers/68e75dd0b6db6435876d4c84https://doi.org/10.1158/2643-3249.bcdsymp24-p23
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A002: Non-alpha IL2R agonist improves CAR T cell therapy by preventing CAR T dysfunction in relapsed/refractory large B cell lymphoma2026
  2. 2The role of RhoA in diffuse large B-cell lymphoma2025
  3. 3Abstract PD9-04: Context-dependent tumor suppressor role of RHOA in breast cancer through cooperation with CDH1 loss2026
  4. 4Abstract B014: Investigating universal mechanisms of leukemic cell resistance to CAR-T cell therapy2026
  5. 5Abstract A004: ROR1 upregulation after CD19-CAR T-cell relapse in mantle cell lymphoma reveals a targetable vulnerability for ROR1-directed bispecific modalities2026