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December 8, 2025BloodOpen Access

The role of RhoA in diffuse large B-cell lymphoma

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Authors

RKRamesh KrishnanBHBjörn HäuplNDNiklas Dienstbier

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Overview

Research finds that RhoA mutations influence BCR signaling in DLBCL, suggesting new targeted therapies.

Key Points

  • To investigate the role of RhoA and its mutations in diffuse large B-cell lymphoma (DLBCL).
  • Examined the effects of RhoA inhibitors and CRISPR screening
  • Utilized quantitative proteomics and proximity ligation assays
  • Employed super-resolution microscopy and RNA sequencing
  • Identified RhoA's critical role in BCR signaling and cell survival
  • Mutations in RhoA led to enhanced BCR clustering and NF-kB activation
  • Highlighted implications for targeted therapies in RhoA-mutated DLBCL

Cite This Study

Krishnan et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db1chttps://doi.org/10.1182/blood-2025-5308
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract P23: RHOA inactivation subverts IFN-γ response and promotes antigen escape in CAR-T resistant diffuse large B-cell lymphoma2024
  2. 2Abstract PD9-04: Context-dependent tumor suppressor role of RHOA in breast cancer through cooperation with CDH1 loss2026
  3. 3Abstract 4388: Tumor-associated RhoA mutants interact with effectors in both GDP- and GTP-bound states2024
  4. 4RhoJ promotes the progression of clear cell renal cell carcinoma via the TNF-α/NF-κB axis2025 · 1 citations
  5. 5Profiling Ten <scp>RHO GTPases</scp> in Myeloid Malignancies Reveals Distinct Expression Patterns and Prognostic Associations2026