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LHON this was 1st disease to be related with mitochondrial DNA point mutation , and this is maternally inherited.LHON may be systemic disorder with manifestation in organ other than eye ( optic nerve) but is multi system disorder in that involvement of CNS, Ear, Heart, bone marrow, kidney, arteries or PNS.Multisystem involvement may start before or after the visual acuity , where the eye can't see object as clearly as usual.Due to LHON we can face blindness.
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Bhakti et al. (2024) studied this question.
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