March 1, 2024HeliyonOpen Access

Electroacupuncture regulates histone acetylation of Bcl-2 and Caspase-3 genes to improve ischemic stroke injury

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Electroacupuncture mitigates ischemic stroke damage by reducing infarct size, blood-brain barrier disruption, and apoptotic cell death in brain tissue.
Bcl-2 promoter enrichment of H3K9ace and H3K27ace increased alongside reduced caspase-3 promoter acetylation, an effect blocked by a histone acetyltransferase inhibitor.
Assessment using middle cerebral artery occlusion in rats evaluated neuroprotection via chromatin immunoprecipitation and histology assays.
Epigenetic modification via electroacupuncture supports neuronal survival; rat model limits direct clinical translation, requiring further animal validation.

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Preclinical study demonstrates electroacupuncture limits ischemic stroke injury in rats, indicating an epigenetic mechanism of neuroprotection.

Meng et al. (2024) studied this question.

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Preclinical study demonstrates electroacupuncture limits ischemic stroke injury in rats, indicating an epigenetic mechanism of neuroprotection.