The Simplified Thrombo-Inflammatory Score as a Novel Predictor of All-Cause Mortality in Patients with Heart Failure: A Retrospective Cohort Study

Background:The simplified thrombo-inflammatory score (sTIPS) has recently emerged as a novel prognostic score.Hence, we investigated the prognostic value of sTIPS for predicting long-term mortality in patients with heart failure (HF).Methods: A total of 3741 patients were analyzed in this study.The sTIPS was calculated based on the white blood cell count (WBC) and the mean platelet volume to platelet count (MPV/PC) ratio at admission.The mean follow-up time was 22.75 months.Multivariable Cox regression analyses were used to investigate the associations between the sTIPS and all-cause mortality (ACM).Results: In the whole study population, multivariate Cox regression analysis showed that patients in both the sTIPS 2 and sTIPS 1 groups had significantly increased risk of ACM as compared with patients in the sTIPS 0 group (hazard ratio [HR]=1.706,95% confidence interval [CI]: 1.405-2.072,P<0.001 and HR = 1.431, 95% CI 1.270-1.612,P<0.001).The same significant trend was observed in heart failure with preserved ejection fraction (HFpEF) patients (sTIPS1 vs sTIPS0: HR = 1.366, 95% CI 1.100-1.697,P = 0.005; sTIPS2 vs sTIPS0: HR = 1.995, 95% CI 1.460-2.725,P<0.001).However, only sTIPS 1 group had a significantly increased the risk of ACM compared to the sTIPS 0 group among patients with HFmrEF (sTIPS1 vs sTIPS0: HR = 1.648, 95% CI 1.238-2.194,P = 0.001) and HFrEF (sTIPS1 vs sTIPS0: HR = 1.322, 95% CI 1.021-1.712,P = 0.035).Conclusion: sTIPS is useful in predicting risk for long-term mortality in patients with HF.