Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 15, 2026MedicineOpen Access

Association of systemic immune-inflammation index (SII) with 28-day all-cause mortality in acute heart failure: A retrospective cohort study

View Full Paper
Ask AI
Bookmark
Share

Authors

JZJianhua ZhangZZZiqi ZhangZYZi Yan

Discussion

Loading...

Member takes

Overview

Retrospective cohort study identifies SII as a prognostic biomarker for 28-day mortality risk stratification in acute heart failure.

Key Points

  • This research evaluates the relationship between systemic immune-inflammation index (SII) and 28-day all-cause mortality in acute heart failure.
  • Conducted a retrospective cohort study using Medical Information Mart for Intensive Care IV database.
  • Included patients diagnosed with acute heart failure during first ICU admission; excluded short stays and missing lab data.
  • Calculated SII from initial lab values (platelet count x neutrophil count/lymphocyte count).
  • Performed Kaplan–Meier survival analysis and multivariable Cox proportional hazards modeling to assess mortality associations.
  • 5482 patients were included in the analysis.
  • Higher SII tertiles correlated with increased 28-day mortality (hazard ratios of 1.485 for middle and 2.497 for highest tertiles).
  • Significant dose–response relationship observed between SII and mortality.
  • SII improved mortality discrimination when added to existing scoring systems.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff5c83145bc643d1bb8ehttps://doi.org/10.1097/md.0000000000048027
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating the prognostic value of systemic immune‐inflammatory index in patients with acute decompensated heart failure2024 · 12 citations
  2. 2Association of Systemic Immune-inflammation Index With Short-Term Mortality of Congestive Heart Failure: A Retrospective Cohort Study2021 · 9 citations
  3. 3Association of Systemic Immune-Inflammation Index With Short-Term Mortality of Congestive Heart Failure: A Retrospective Cohort Study2021 · 98 citations
  4. 4Systemic Immune-Inflammation Index as A Predictor of Mortality and Rehospitalization in Heart Failure Patients2024
  5. 5Association of systemic immune-inflammation index with adverse outcomes in heart failure and preserved ejection fraction2025 · 9 citations