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September 10, 2025Journal of Translational MedicineOpen Access

Association of systemic immune-inflammation index with adverse outcomes in heart failure and preserved ejection fraction

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Authors

AMAbdul‐Quddus MohammedTongji UniversityYLYongqiang LuoTongji UniversityYCYi-Chuan ChenTongji University

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Overview

Analysis of SII shows increased risk of cardiovascular death and rehospitalization in HFpEF patients, indicating its potential as a reliable biomarker.

Key Points

  • Higher systemic immune-inflammation index values are linked to increased risk of death and heart failure rehospitalization.
  • In a cohort of 458 HFpEF patients, 46.1% experienced adverse composite events over an average follow-up of 41.8 months.
  • Diabetic patients exhibited a stronger association between high SII levels and adverse outcomes compared to non-diabetic patients.
  • Systemic immune-inflammation index demonstrated superior prognostic accuracy over other inflammatory markers in predicting heart failure outcomes.

Cite This Study

Mohammed et al. (2025) studied this question.

synapsesocial.com/papers/68c1d03e54b1d3bfb60f7203https://doi.org/10.1186/s12967-025-06964-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systemic Immune-Inflammation Index Outperforms Conventional Inflammatory Markers in Predicting Cardiovascular Outcomes in Heart Failure with Preserved Ejection Fraction2026 · 5 citations
  2. 2Diagnostic and prognostic value of systemic immune-inflammation index for heart failure: a systematic review and meta-analysis2025
  3. 3Prognostic impact of systemic immune inflammatory index in patients with reduced ejection fraction heart failure2025 · 6 citations
  4. 4Association of systemic immune-inflammation index (SII) with 28-day all-cause mortality in acute heart failure: A retrospective cohort study2026
  5. 5Systemic Immune-Inflammatory Index as a Prognostic Biomarker in Patients with Heart Failure: A Comprehensive Analysis2025 · 3 citations