787 Pseudoangiomatous stromal hyperplasia: study of three cases

Introduction/Background Pseudoangiomatous breast stromal hyperplasia (PASH) is a rare benign lesion, mainly affecting pre-menopausal women. It is rarely revealed by a clinically palpable nodule, and is more frequently discovered incidentally on histological examination of breast biopsies taken in the context of benign or malignant lesions of the breast. On histological examination, it is characterised by pseudo-vascular clefts in a collagenised stroma. Clinical examination reveals a benign nodule (mobile, painless, well limited) of variable size. Methodology We report a retrospective study of 3 patients registered at the CHU HASSAN II of Fez, between 2022 and 2023, who underwent surgery for a palpable breast nodule suggestive of PASH on biopsy. Results Our patients were aged 45, 25 and 24 years respectively. The average size of the nodule was 4 cm, clinically palpable and most often in the form of an opacity classified ACR 4a on ultrasound mammography. Histology showed a non-encapsulated, fibrous lesion containing a network of anastomotic pseudo-vascular slits, and immunohistochemistry ruled out breast angiosarcoma. Our patients underwent lumpectomy and are currently under clinical and radiological surveillance, with no signs of recurrence to date. Conclusion PASH is a benign conjunctival lesion of the breast that must be completely removed and monitored at a later date, due to the risk of recurrence in up to 20% of cases Disclosures The authors declare no conflicts of interest.