663 MEP045 – The role of sleep latency in predicting mental health problems after concussion

AbstractBackground Growing research suggests sleep quality and mental health changes following concussion are associated, yet few have examined this relationship among adolescents. An adolescent's sleep patterns may influence their perception of mental health and subsequent recovery, identifying sleep-related risk factors after concussion may be one key element to understand risk of poor mental health outcomes.Objective Determine how wrist-worn actigraphy measures of sleep latency (time taken to fall asleep) among adolescent males and females following a diagnosed concussion were associated with outcomes of anxiety and depression.Design Prospective cohort study.Setting Sports medicine clinic.Patients Adolescent males and females were diagnosed and assessed within two weeks post-concussion and returned 2–4 weeks later for follow-up assessment. Interventions Following initial assessment participant's sleep was recorded via wrist-worn actigraphy device each night for 7 nights.Main Outcome Measurements After the 7-night sleep monitoring period, participants returned for follow-up assessment and self-reported anxiety and depressive symptoms on the Pediatric Patient Reported Outcomes Measurement (PROMIS) Global Pediatric 25 instrument. Separate linear regression models by sex were constructed to determine the independent association between PROMIS subscales and the potential predictor variable of sleep latency.Results We enrolled 50 participants (Females=28; Males = 22), initially assessed 7.6 ± 3.6 days post-concussion. For adolescent males, decreased sleep latency was independently associated with decreased symptoms of anxiety (p=.044) and depression (p=.052) at follow-up. In contrast, for adolescent females sleep latency was not predictive of symptoms of anxiety or depression (Table 1).Conclusion Our data indicate that male adolescents demonstrated an association between sleep latency in the subacute phase following a concussion and prolonged symptoms of anxiety and depression up to 4 weeks after injury. These sex differences underscore the necessity of accounting for sex-specific variations when assessing the relationship of mental health and sleep patterns throughout concussion recovery.View this table:View inline View popup Abstract 663 Table 1 Linear Regression of sleep latency predictive of Anxiety and Depression between female and male adolescents. *p<.05 (significantly associated with anxiety and depression)