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March 1, 2024Poster presentationsOpen Access

P06.01 Gain-of-function CARD11 signalling in B cells causes pathological lymphoproliferative disease in mice which is strictly dependent on MALT1 activity

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Authors

AKAndreas KratzertDynamic Biosensors (Germany)EMEmma MorrishTechnical University of MunichSKSJ KepplerTechnical University of Munich

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Cite This Study

Kratzert et al. (2024) studied this question.

synapsesocial.com/papers/68e7692cb6db6435876df112https://doi.org/10.1136/jitc-2024-itoc10.42
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 6986: Oncogenic CARD11 enhances marginal zone B cell survival by potentiating the non-canonical NF-κB pathway2024
  2. 2Mechanistic Insights Into Immune Cell Dysregulation Mediated by Novel Heterozygous Variants in CARD11 and MALT12026
  3. 3Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function2026
  4. 4The CARD11-BCL10-MALT1 (CBM) Complex Regulates Nutrient Transport and mTORC1 Activation to Shape CD4+ T Cell Differentiation 22524392026
  5. 5The CARD11-BCL10-MALT1 (CBM) complex governs activation-induced upregulation of key nutrient transporters and metabolic reprogramming in human CD4+ T cells 37672025