Abstract 2247 Identifying and exploiting cell-state dependent metabolic networks

Mammalian cell survival and proliferation requires energy, reducing equivalents, and biosynthetic precursors required to maintain basic cellular processes. To meet these demands, cells take up and catabolize nutrients via an intricate network of metabolic pathways. Despite requiring a fixed set of metabolic intermediates in order to maintain homeostasis and increase biomass, mammalian cells exhibit notable metabolic flexibility and heterogeneity. As cells change their state, through changes in growth, proliferation or differentiation, they reconfigure their metabolic networks to meet cell-state specific demands. In this presentation, I will discuss our latest work on how cell-type specific metabolic programs are established and how these metabolic reorganizations support cell behaviors. By unraveling the metabolic rearrangements that occur during cell state transitions, our work aims to determine how metabolism supports normal cell function and how metabolic aberrations contribute to disease.