Abstract 1425 Standardization and Harmonization by the International Lipidomics Society

Mass spectrometry (MS)-based lipidomics has revolutionized lipid research. However, numerous studies are reporting poor quality lipidomics data with misidentification and inaccurate/inappropriate quantification of lipid molecules. In 2018 we launched the Lipidomics Standards Initiative (LSI; https://lipidomicstandards.org), an open-access web-resource to both describe and promote guidelines for minimal acceptable lipidomics data quality. LSI covers the main analytical lipidomics steps of traditional lipidomics workflows including how to 1) collect and store samples, 2) extract lipids, 3) perform mass spectrometric analysis, 4) perform data processing and 5) reporting. To provide transparency in reporting we have now launched the online reporting system "Lipidomics Minimal Reporting Checklist" (https://lipidomicstandards.org/reporting_checklist/) (McDonald et al. 2022). The checklist has multiple uses but is foremost recommended as included supplementary material in publications containing lipidomic data. Today, LSI is integrated as an interest group into the International Lipidomics Society (ILS; https://lipidomicssociety.org) to coordinate international community-wide communication. Consensus guidelines will foster data quality, provide a language for data comparison/exchange and advance lipidomics to a genuine analytical tool from basic research to clinical applications.