Narrative review outlines periostin mechanisms in mechanical load-bearing bone tissues, highlighting its signaling regulation in osteoporosis.
Periostin, as a unique extracellular matrix, is mainly produced during ontogeny and in adult connective tissues that bear mechanical loads, such as heart valves, skin, periodontal ligaments, tendons, and bones. By binding to the integrin on the cell surface and activating Wnt/β-catenin, NF-κB, Fak and other signaling pathways, it regulates the tissues
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Yuan et al. (2024) studied this question.
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