Cover Feature: Empowering Protein Engineering through Recombination of Beneficial Substitutions (Chem. Eur. J. 16/2024)

Various substitution recombination methods in the field of protein engineering are described in this paper. The enzyme properties can be empowered by experimental and computer-assisted recombination methods. This cover feature shows the tree of substitution recombination in an impressionistic style, where the branches are made up of numerous protein sequences and the orbs on the branches symbolize beneficial substitutions; and the recombination tree can be ever-changing… More information can be found in the Review by X. Li, H. Cui and co-workers (DOI: 10.1002/chem.202303889).