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February 25, 2024Open Access

Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

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KGKhaldoun GharzeddineCPCristina Gonzalez PietroMMMarie Malier

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Cite This Study

Gharzeddine et al. (2024) studied this question.

synapsesocial.com/papers/68e77b26b6db6435876ef51chttps://doi.org/10.1101/2024.02.22.581558
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancers2024 · 7 citations
  2. 2CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer2024 · 83 citations
  3. 3CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8<sup>+</sup>T cells2013 · 380 citations
  4. 4Discovery of a Novel CSF-1R Inhibitor with Highly Improved Pharmacokinetic Profiles and Superior Efficacy in Colorectal Cancer Immunotherapy2024 · 9 citations
  5. 5Targeting CSF1R in myeloid-derived suppressor cells: insights into its immunomodulatory functions in colorectal cancer and therapeutic implications2024 · 4 citations