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April 9, 2024Journal of Medicinal Chemistry

Discovery of a Novel CSF-1R Inhibitor with Highly Improved Pharmacokinetic Profiles and Superior Efficacy in Colorectal Cancer Immunotherapy

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Authors

QLQi LvHYHongqiong YangDWDan Wang

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Lv et al. (2024) studied this question.

synapsesocial.com/papers/68e6fb9db6db643587676567https://doi.org/10.1021/acs.jmedchem.4c00508
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer2024 · 83 citations
  2. 2Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancers2024 · 7 citations
  3. 3Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers2024 · 1 citations
  4. 4Abstract 2671: Sustained inhibition of CSF1R signaling effectively augments antitumor immune responses through inhibiting tumor-associated macrophages2024
  5. 5CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8<sup>+</sup>T cells2013 · 380 citations