October 9, 2025Open Access

From GWAS to Translational Insights: Comprehensive Genetic Analysis of Nephrotic Syndrome from Multiple Populations

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Discussion

Genome-wide association study identifies genetic loci in nephrotic syndrome, suggesting ancestry-informed targets for therapy.

Genetic analysis found 37 loci associated with nephrotic syndrome risk, revealing novel associations.
The strongest association was with variant DRB103:01:01G in European ancestry, with OR 2.01.
Fine-mapping and eQTL mapping highlighted key gene-tissue associations, particularly in renal tissues.
Findings suggest shared genetic etiology between adult and pediatric nephrotic syndrome, with implications for therapy.

Breeyear et al. (2025) studied this question.

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