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October 9, 2025Circulation Research

Abstract Wed011: Histone Deacetylase 7 protects against pathologic cardiac hypertrophy

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Authors

JBJin BuSHSophie HandSGShuliang Guo

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Overview

Molecular analysis shows that HDAC7 reduces hypertrophic responses in cardiomyocytes, suggesting potential therapeutic applications.

Key Points

  • Overexpression of HDAC7 significantly reduces hypertrophic responses in both neonatal and adult cardiomyocytes.
  • Experimental results demonstrate that HDAC7 interactions with MEF2D play a crucial role in mitigating cardiac hypertrophy.
  • Cultured neonatal cardiomyocytes showed reduced cell size and lower hypertrophic gene expression following HDAC7 overexpression.
  • HDAC7's protective effects are compromised when its binding capability with MEF2D is mutated.

Cite This Study

Bu et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb10https://doi.org/10.1161/res.137.suppl_1.wed011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Histone Deacetylase 7 protects against pathologic cardiac hypertrophy2026 · 1 citations
  2. 2Suppression of Class I and II Histone Deacetylases Blunts Pressure-Overload Cardiac Hypertrophy2006 · 377 citations
  3. 3Inhibition of Histone Deacetylation Blocks Cardiac Hypertrophy Induced by Angiotensin II Infusion and Aortic Banding2005 · 372 citations
  4. 4Regulation of Acetylation of Histone Deacetylase 2 by p300/CBP-Associated Factor/Histone Deacetylase 5 in the Development of Cardiac Hypertrophy2014 · 77 citations
  5. 5Targeting histone deacetylases for heart failure2009 · 42 citations