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October 9, 2025Circulation Research

Abstract Wed044: Dynamic Regulation and Functional Role of HSPB7 in Pathological and Physiological Cardiac Hypertrophy in vitro and in vivo

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Authors

MQMeixi QuanQZQiulian ZhouJGJ. Sawalla Guseh

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Overview

Dynamic regulation of hspb7 influences cardiac hypertrophy outcomes, suggesting therapeutic potential.

Key Points

  • HSPB7 overexpression mitigated pathological hypertrophy, improving cardiac function in vivo after TAC.
  • In pathological conditions, HSPB7 expression changes dynamically, highlighting its dual role in hypertrophy.
  • Functional studies showed that HSPB7 loss exacerbated mitochondrial dysfunction and pathological hypertrophy.
  • Proteomics identified binding partners linked to HSPB7's role in cardiac hypertrophy and heart health.

Cite This Study

Quan et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877df3https://doi.org/10.1161/res.137.suppl_1.wed044
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract Wed011: Histone Deacetylase 7 protects against pathologic cardiac hypertrophy2025
  2. 2HSBP7 Rescue of a Titin Cardiomyopathy Identified by Morphological Profiling2024 · 1 citations
  3. 3Histone Deacetylase 7 protects against pathologic cardiac hypertrophy2026 · 1 citations
  4. 4HSPB2 Is Dispensable for the Cardiac Hypertrophic Response but Reduces Mitochondrial Energetics following Pressure Overload In Mice2012 · 21 citations
  5. 5Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling2018 · 40 citations