Key result
GPC3 knockdown improves left ventricular function and reduces post-MI cardiac remodeling in mice.
Why the study?
Does GPC3 knockdown reduce cardiac fibrosis and improve left ventricular function post-myocardial infarction in preclinical models?
Does GPC3 knockdown reduce cardiac fibrosis and improve left ventricular function post-myocardial infarction in preclinical models?
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Inhibiting GPC3 in cardiac fibroblasts reduces myofibroblast differentiation and improves post-MI cardiac remodeling and LV function in preclinical models.
Joladarashi et al. (2025) studied Heart failure and myocardial infarction. AAV9-periostin promoter mediated knockdown of GPC3 was evaluated on Left ventricular function and cardiac remodeling. AAV9-mediated knockdown of GPC3 improved left ventricular function and reduced cardiac remodeling post-myocardial infarction in mice.
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