Key result
Cardiomyocyte-specific GSK-3β knockout triggers severe spontaneous systolic dysfunction and adverse dilative cardiac remodeling in mice.
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Cardiomyocyte GSK-3β plays a critical role in maintaining cardiac homeostasis by regulating the crosstalk between fibroblasts and immune cells, preventing fibro-inflammatory remodeling and systolic dysfunction.
Bhati et al. (2025) studied Cardiac remodeling and homeostasis. Cardiomyocyte-specific GSK-3β knockout (CM-GSK-3β-KO) vs. Control mice was evaluated on Cardiac function, structural remodeling, and immune cell infiltration. Cardiomyocyte-specific GSK-3β knockout in mice led to severe spontaneous systolic dysfunction, dilative cardiac remodeling, and increased pro-inflammatory immune cell infiltration.
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