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October 9, 2025Circulation Research0 citations

C5ORF51/RIMOC1 Role in Adult Cardiomyocyte Maturation and Quiescence

Abstract Thu007: C5ORF51/RIMOC1 is Required for Adult Cardiomyocyte Maturation and Quiescence

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Authors

SVSitthixai VongdeuaneDFDaniela T. FullerYLYijia Li

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Overview

This study demonstrates that C5ORF51 is crucial for cardiomyocyte maturation and proliferation, indicating its potential for cardiac therapies.

Key Points

  • C5ORF51 deletion leads to increased cardiomyocyte proliferation in adult mice without affecting cardiac function.
  • Histological analyses show significantly higher Ki67, pHH3, and EdU positive cells in C5x-icKO hearts compared to controls.
  • Echocardiographic data reveals no differences in cardiac function metrics like ejection fraction between groups.
  • C5ORF51 regulates cell cycle reentry in cardiomyocytes via YAP/TAZ-TEAD1 signaling pathways.

Cite This Study

Vongdeuane et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb3bhttps://doi.org/10.1161/res.137.suppl_1.thu007
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