Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 9, 2025Circulation Research

Abstract Thu024: Spontaneously proliferating cardiomyocytes are sensitized to proliferate through retinoic acid dependent signaling

View Full Paper
Ask AI
Bookmark
Share

Authors

ASAbou Bakr M. SalamaQOQinghui OuMDMarc Dwenger

Discussion

Loading...

Member takes

Overview

This analysis demonstrates retinoic acid's role in promoting cardiomyocyte proliferation via CD36 and PPARδ signaling pathways.

Key Points

  • Retinoic acid enhances cardiomyocyte proliferation in neonatal hearts, indicating its potential therapeutic role.
  • Global CD36 knockout mice exhibited impaired proliferation and smaller hearts, highlighting CD36's significance.
  • Spatial transcriptomics localized proliferative cardiomyocytes, showing Cd36 expression linked to retinoic acid signaling.
  • PPARδ overexpression in neonatal mice improved cardiomyocyte regeneration post-injury, supporting target identification for heart therapies.

Cite This Study

Salama et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fbd2https://doi.org/10.1161/res.137.suppl_1.thu024
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reintroducing FABP5 in adulthood activates cell cycle in cardiomyocytes2026
  2. 2Dynamic upregulation of retinoic acid signal in the early postnatal murine heart promotes cardiomyocyte cell cycle exit and maturation2024 · 1 citations
  3. 3To proliferate or not to proliferate2010 · 7 citations
  4. 4Selective cardiomyocyte loss triggers myocardial regeneration via miR221 driven activation of cardiac stem cells and p57 suppression2026
  5. 5Exploring cardiomyocytes-endothelial cell communication to promote cardiac revascularization and regeneration2026