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October 9, 2025Circulation Research

Abstract Fri049: Exploring the Role of Interferon Responsive Neutrophils in the Development of HFpEF

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Authors

JWJennifer L. WallerMBMaegan L. BrockmanTSTriniti Scruggs

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Overview

This study explores neutrophil responses to interferon in heart failure with preserved ejection fraction, suggesting implications for inflammation.

Key Points

  • The study demonstrates that neutrophils' response to interferon impacts inflammation in a model of HFpEF.
  • Flow cytometry data indicate a significant modulation of inflammatory cell abundance due to knockout of the interferon receptor.
  • Surgical alterations indicate no significant change in cardiac function, despite differences in inflammatory markers.
  • HFpEF development was assessed in mice subjected to a high-fat diet, revealing insights into potential therapeutic targets.

Cite This Study

Waller et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fbd6https://doi.org/10.1161/res.137.suppl_1.fri049
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative immune profiling in HFpEF: cross-species insights into inflammation and mitochondrial dysfunction2025
  2. 2Characterisation and treatment of the cardiometabolic HFpEF phenogroup2026 · 1 citations
  3. 3Myocardial Inflammatory Remodeling in HFpEF: Potential Role of Chemoreflex-Induced Low-Grade Inflammation2026
  4. 4Circulating Immune Cell Signature Analysis in HFpEF Across Species2025 · 7 citations
  5. 5Impact of Voluntary Exercise on Systemic Inflammation in a 2? Hit Model of Heart Failure With Preserved Ejection Fraction2025