Relationships between Meat and Fish Consumption, N-Acetyltransferase 2 Genotypes, and Colorectal Cancer Risk: A Case–Control Study in the Basque Country

first_page Download PDF settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Relationships between Meat and Fish Consumption, N-Acetyltransferase 2 Genotypes, and Colorectal Cancer Risk: A Case–Control Study in the Basque Country † by Naiara Martinez-PerezNaiara Martinez-Perez SciProfiles Scilit Preprints.org Google Scholar 1,2, Olatz Echezarreta-RuizOlatz Echezarreta-Ruiz SciProfiles Scilit Preprints.org Google Scholar 3, Iker Alegria-LertxundiIker Alegria-Lertxundi SciProfiles Scilit Preprints.org Google Scholar 3, Marian M. de PancorboMarian M. de Pancorbo SciProfiles Scilit Preprints.org Google Scholar 2,4, Felix OlasagastiFelix Olasagasti SciProfiles Scilit Preprints.org Google Scholar 2,5,6, Harkaitz EguiraunHarkaitz Eguiraun SciProfiles Scilit Preprints.org Google Scholar 2,7 and Marta Arroyo-IzagaMarta Arroyo-Izaga SciProfiles Scilit Preprints.org Google Scholar 2,3,6,* 1 Department of Nursing I, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48900 Leioa, Spain 2 BIOMICs Research Group, Microfluidics & BIOMICs Cluster UPV/EHU, Lascaray Research Center, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain 3 Department of Pharmacy and Food Sciences, Faculty of Pharmacy, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain 4 Department of Z. and Cellular Biology A., Faculty of Pharmacy, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain 5 Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain 6 Bioaraba, BA04.03, 01006 Vitoria-Gasteiz, Spain 7 Department of Graphic Design & Engineering Projects, Faculty of Engineering in Bilbao, University of the Basque Country UPV/EHU, 48013 Bilbao, Spain * Author to whom correspondence should be addressed. † Presented at the 14th European Nutrition Conference FENS 2023, Belgrade, Serbia, 14–17 November 2023. Proceedings 2023, 91(1), 358; https://doi.org/10.3390/proceedings2023091358 Published: 21 February 2024 (This article belongs to the Proceedings of The 14th European Nutrition Conference FENS 2023) Download keyboard_arrow_down Download PDF Download PDF with Cover Download XML Download Epub Versions Notes Keywords: N-acetyltransferase-2; diet; meat; genetic polymorphisms; colorectal cancer Background and objective: High consumption of haem iron-rich foods has been associated with colorectal cancer (CRC) risk. However, genetic susceptibility's role remains unclear. Therefore, we studied possible interactions between variants in the N-Acetyltransferase 2 (NAT2) gene, involved in carcinogenic metabolism, and meat and fish consumption with CRC risk. Methods: This observational study includes 229 patients diagnosed with CRC and 229 age- and sex-matched controls from a population-based bowel cancer screening program. Intake of fish and red, white, processed, and grilled meat, as well as three slow NAT2 acetylator variants (rs1801280, rs1799930, and rs1799931), was analyzed. Logistic conditional regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CI) for CRC risk. Results: The CT genotype of rs1801280 and AA genotype of rs1799930 may increase CRC risk (adjusted model: OR = 2.91, 95% CI 1.50–5.64, p = 0.002; OR = 0.24, 95% CI 0.08–0.74, p = 0.013). Moreover, the consumption of processed meat and of red meat were both associated with the risk of CRC (adjusted model, processed meat tertile 2 vs. 1, OR = 3.20, 95% CI 1.37–7.49, p = 0.007; red and processed meat, tertile 3 vs. 1, OR = 2.09, 95% CI 1.04–4.21, p = 0.039). A significant interaction was observed between white meat intake and the CC + CT genotype of rs1801280 (tertile 3 vs. 1, OR = 4.71, 95% CI 1.56–14.24, p interaction = 0.001). Discussion: Confirming other authors' works [1,2], our data suggest that the "slow" variants NAT2 341T>C and 590G>A and the intake of red and processed meat were related to CRC risk. Additionally, the variant NAT2 341T>C may modify the association of white meat intake with CRC risk. Author ContributionsConceptualization, M.M.d.P. and M.A.-I.; investigation (data collection), I.A.-L. and M.A.-I.; formal analysis, I.A.-L., O.E.-R. and M.A.-I.; writing—original draft, review & editing, I.A.-L., O.E.-R., N.M.-P., M.M.d.P., F.O., H.E. and M.A.-I.; supervision, M.M.d.P. and M.A.-I.; funding acquisition, I.A.-L., M.M.d.P. and M.A.-I. All authors have read and agreed to the published version of the manuscript.FundingThis work was supported by the Basque Government (Department of Health and Consumer Affairs, No. 2011111153; Saiotek programme, No. S-PE12UN058; BIOMICs Research Group, Microfluidics & BIOMICs Cluster of the University of the Basque Country UPV/EHU, No. IT1633-22). I.A.-L. was funded by a pre-doctoral grant from the Basque Government (PRE_2014_1_161–PRE_2017_2_0006).Institutional Review Board StatementThis study was conducted according to the guidelines laid down in the Declaration of Helsinki, and all procedures involving patients were approved by the Clinical Research Ethics Committee of the Basque Country (protocol code PI2011006, data of approval 23 March 2012; and PI2014042, data of approval 28 May 2014).Informed Consent StatementWritten informed consent was obtained from all the study participants.Data Availability StatementData are to be made available only via a request to the corresponding author. Data will be provided only after the acceptance and signature of a formal data-sharing agreement.Conflicts of InterestThe authors declare no conflict of interest.Referencesda Silva, T.D.; Felipe, A.V.; de Lima, J.M.; Oshima, C.T.; Forones, N.M. N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer. World J. 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Share and Cite MDPI and ACS Style Martinez-Perez, N.; Echezarreta-Ruiz, O.; Alegria-Lertxundi, I.; M. de Pancorbo, M.; Olasagasti, F.; Eguiraun, H.; Arroyo-Izaga, M. Relationships between Meat and Fish Consumption, N-Acetyltransferase 2 Genotypes, and Colorectal Cancer Risk: A Case–Control Study in the Basque Country. Proceedings 2023, 91, 358. https://doi.org/10.3390/proceedings2023091358 AMA Style Martinez-Perez N, Echezarreta-Ruiz O, Alegria-Lertxundi I, M. de Pancorbo M, Olasagasti F, Eguiraun H, Arroyo-Izaga M. Relationships between Meat and Fish Consumption, N-Acetyltransferase 2 Genotypes, and Colorectal Cancer Risk: A Case–Control Study in the Basque Country. Proceedings. 2023; 91(1):358. https://doi.org/10.3390/proceedings2023091358 Chicago/Turabian Style Martinez-Perez, Naiara, Olatz Echezarreta-Ruiz, Iker Alegria-Lertxundi, Marian M. de Pancorbo, Felix Olasagasti, Harkaitz Eguiraun, and Marta Arroyo-Izaga. 2023. "Relationships between Meat and Fish Consumption, N-Acetyltransferase 2 Genotypes, and Colorectal Cancer Risk: A Case–Control Study in the Basque Country" Proceedings 91, no. 1: 358. https://doi.org/10.3390/proceedings2023091358 Article Metrics No No Article Access Statistics Multiple requests from the same IP address are counted as one view.