Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk

Letters16 September 2014Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary RiskEmanuele Di Angelantonio, MD, MSc, PhD, Rajiv Chowdhury, MD, PhD, Nita G. Forouhi, PhD, and John Danesh, FRCPEmanuele Di Angelantonio, MD, MSc, PhDFrom University of Cambridge, Cambridge, United Kingdom; UK Medical Research Council Epidemiology Unit, Cambridge, United Kingdom; and University of Cambridge, Cambridge, United Kingdom., Rajiv Chowdhury, MD, PhDFrom University of Cambridge, Cambridge, United Kingdom; UK Medical Research Council Epidemiology Unit, Cambridge, United Kingdom; and University of Cambridge, Cambridge, United Kingdom., Nita G. Forouhi, PhDFrom University of Cambridge, Cambridge, United Kingdom; UK Medical Research Council Epidemiology Unit, Cambridge, United Kingdom; and University of Cambridge, Cambridge, United Kingdom., and John Danesh, FRCPFrom University of Cambridge, Cambridge, United Kingdom; UK Medical Research Council Epidemiology Unit, Cambridge, United Kingdom; and University of Cambridge, Cambridge, United Kingdom.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5018-11 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Our systematic review and meta-analysis of the published literature aimed a priori to quantify 3 aspects of the evidence on fatty acids and CHD.First, we considered results on self-reported dietary fatty acid intake from 32 prospective studies (512 420 participants, 15 945 cases of CHD), constituting more than 90% of the relevant data published before July 2013. We found essentially null associations of SFA, MUFA, and ω-6 PUFAs with CHD, whereas intake of long-chain ω-3 PUFAs was associated with lower risk for CHD and intake of trans fatty acids was associated with higher risk. In contrast with ...References1. Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, et al. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr. 2009;89:1425-32. [PMID: 19211817] doi:10.3945/ajcn.2008.27124 CrossrefMedlineGoogle Scholar2. Danesh J, Saracci R, Berglund G, Feskens E, Overvad K, Panico S, et al; EPIC-Heart. EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries. Eur J Epidemiol. 2007;22:129-41. [PMID: 17295097] CrossrefMedlineGoogle Scholar3. Bonds DE, Harrington M, Worrall BB, Bertoni AG, Eaton CB, Hsia J, et al; Writing Group for the AREDS2 Research Group. Effect of long-chain ω-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA Intern Med. 2014;174:763-71. [PMID: 24638908] doi:10.1001/jamainternmed.2014.328 CrossrefMedlineGoogle Scholar4. Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ. 2013;346:e8707. [PMID: 23386268] doi:10.1136/bmj.e8707 CrossrefMedlineGoogle Scholar5. Clarke R, Frost C, Collins R, Appleby P, Peto R. Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. BMJ. 1997;314:112-7. [PMID: 9006469] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Emanuele Di Angelantonio, MD, MSc, PhD; Rajiv Chowdhury, MD, PhD; Nita G. Forouhi, PhD; John Danesh, FRCPAffiliations: From University of Cambridge, Cambridge, United Kingdom; UK Medical Research Council Epidemiology Unit, Cambridge, United Kingdom; and University of Cambridge, Cambridge, United Kingdom.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-1788. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Rajiv Chowdhury , Samantha Warnakula , Setor Kunutsor , Francesca Crowe , Heather A. Ward , Laura Johnson , Oscar H. Franco , Adam S. Butterworth , Nita G. Forouhi , Simon G. Thompson , Kay-Tee Khaw , Dariush Mozaffarian , John Danesh , and Emanuele Di Angelantonio Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Rajiv Chowdhury , Samantha Warnakula , Setor Kunutsor , Francesca Crowe , Heather A. Ward , Laura Johnson , Oscar H. Franco , Adam S. Butterworth , Nita G. Forouhi , Simon G. Thompson , Kay-Tee Khaw , Dariush Mozaffarian , John Danesh , and Emanuele Di Angelantonio Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Christine Dawczynski , Marcus E. Kleber , Winfried März , Gerhard Jahreis , and Stefan Lorkowski Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Frank Davidoff and Irwin H. Rosenberg Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Bonnie F. Liebman , Martijn B. Katan , and Michael F. Jacobson Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lisa Te Morenga , Jim Mann , and Murray Skeaff Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lukas Schwingshackl and Georg Hoffmann Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Mark McCaulley Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Connie Diekman , Gerard Hornstra , Bethold V. Koletzko , Anna Lartey , and Joyce Nettleton Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Johanna M. Geleijnse , Ingeborg A. Brouwer , and Daan Kromhout Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Adrienne O'Neil and Catherine Itsiopoulos Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Adrienne O'Neil and Catherine Itsiopoulos Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Walter C. Willett , Meir J. Stampfer , and Frank M. Sacks Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Frank Davidoff and Irwin H. Rosenberg Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Christine Dawczynski , Marcus E. Kleber , Winfried März , Gerhard Jahreis , and Stefan Lorkowski Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Johanna M. Geleijnse , Ingeborg A. Brouwer , and Daan Kromhout Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Mark McCaulley Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Bonnie F. Liebman , Martijn B. Katan , and Michael F. Jacobson Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lisa Te Morenga , Jim Mann , and Murray Skeaff Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lukas Schwingshackl and Georg Hoffmann Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Connie Diekman , Gerard Hornstra , Bethold V. Koletzko , Anna Lartey , and Joyce Nettleton Metrics Cited byGlobal Correlates of Cardiovascular Risk: A Comparison of 158 CountriesImpact of the dietary fatty acid intake on C-reactive protein levels in US adultsFood consumption and the actual statistics of cardiovascular diseases: an epidemiological comparison of 42 European countriesNew Insights or Confusion—Is Butter Really Back? 16 September 2014Volume 161, Issue 6Page: 458-459KeywordsAttentionCongenital heart diseaseDisclosureFatsFatty acidsLongitudinal studiesPolyunsaturated fatty acidProspective studiesStatistical dataSystematic reviews ePublished: 16 September 2014 Issue Published: 16 September 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...