This protocol describes a method to extract PCB11 (3,3'-dichlorobiphenyl) and its monohydoxylated metabolites from mouse tissues via a liquid-liquid extraction followed by solid-phase extraction clean-up. The level of PCB11 and OH-PCB11s in the tissue are subsequently measured by gas chromatography-tandem mass spectrometry.
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Li et al. (2024) studied this question.
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