This protocol describes the extraction of 3,3'-dichlorobiphenyl (PCB11) and its monohydoxylated metabolites from mouse blood/serum using liquid-liquid extraction followed by solid-phase extraction clean-up. The levels of PCB11 and OH-PCB11s in the blood/serum samples are subsequently measured by gas chromatography-tandem mass spectrometry.
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Li et al. (2024) studied this question.
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