At present, to the best of our knowledge, there are only a few case reports of IgG4‑related disease (IgG4‑RD) involving myelodysplastic syndrome (MDS), yet the incidence of MDS and IgG4‑RD is increasing in middle‑aged and elderly people. The present study presents a case of MDS combined with IgG4‑RD admitted to Zhejiang Provincial Hospital of Chinese Medicine in September 2022. The (66‑year‑old; male) patient was admitted to the hospital due to hematopenia with an elevated IgG4 index. The diagnosis of MDS combined with IgG4‑RD was confirmed after various exams, including pathological examination. The condition of the patient improved after 3 weeks of hormone therapy, with a significant increase in complete blood count compared with the pre‑treatment period. MDS is a malignant hematological disorder with a high risk of conversion to leukemia, and IgG4‑RD is a systemic immune‑mediated disease with a poor prognosis often associated with malignancy. The present study presents and reviews the literature to better understand the coexistence of these two diseases.
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Wang et al. (2024) studied this question.
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