High-grade Non-Hodgkin\'s Lymphoma Presenting as a Cardiac Tumor

VIDEO CMEpain. 3 Cardiac-specific signs and symptoms include right-sided heart failure, precordial pain, arrhythmia, conduction disorders, pericardial effusion, and cardiac tamponade.By definition, secondary cardiac lymphomas are in stage IV of the disease; hence, diagnosis is usually late, leading to a poor prognosis.TEE is the imaging method of choice when evaluating an intracardiac mass and also for obtaining biopsy samples.However, imaging modalities may not be accurate at differentiating lymphomas from more common cardiac tumors such as myxomas.Definitive diagnosis requires histopathological examination of a biopsy sample, either of the tumor itself, a lymph node, or of pleural/pericardial fluid.Laboratory features that may suggest poor outcomes include raised lactate dehydrogenase, β 2 -microglobulin, and hypoalbuminemia.