Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes

This is the authors' abstract. We don't add key points for this paper.

Context The effect of the active ingredients in traditional Chinese medicines on the activity of cytochrome P450 enzymes (CYP450s) is a critical factor that should be considered in TCM prescriptions. Physcion, the major active ingredient of Rheum spp. (Polygonaceae), possesses wide pharmacological activities.